Overview
Infrastructures of the University Locations (blue) und cooperating partners (green).
Infrastructures of the University Locations (blue) und cooperating partners (green).
We offer excellent basic researchers, clinical scientists, large patient cohorts, community hospitals, health insurers, patient representatives and access to schools.
INTERPLAY brings together 2 Clusters of Excellence, 4 Collaborative Research Centres, 2 Research Units, 2 Research Colleague and 4 Partner Institutions.
Name | Location / Principle Investigators | Objective and funding body |
---|---|---|
Anorexia nervosa registry | A / Herpertz-Dahlmann, B /Legenbauer, E / Hebebrand |
Registry with ca. 700 Anorexia nervosa patients in Germany, Funding: intramural |
RCT | A / Herpertz-Dahlmann | Home treatment program in anorexia nervosa, Funding: G-BA Innovation fund |
PRO-KIND cohort | A / Tenbrock, Wagner | Worldwide largest cohort of treatment-naive patients with pediatric rheumatic diseases (app. 500 patients), Funding: G-BA Innovation fund |
CEDATA | A / Wagner | Long term follow up of mor than 5.000 pediaric patients with inflammatory bowel disease, national register |
JODA-MALTREAT database | A / Konrad | Joint database for studies on the effects of childhood maltreatment, Funding: BMBF |
ESCAlife | A / Herpertz-Dahlmann, B / Holtmann, C / Doepfner |
Stepped Care of ADHD along the life-span, Funding: BMBF |
Mighty U | B / Lücke | Program to support child patients in therapy through virtual reality, Funding: BMBF |
CARE FAM NET´ | B / Lücke, C / Bender E / Hebebrand |
The CARE-FAM-NET (incl. > 40 consortium partners) aimed to close the existing gap in psychosocial care for families with affected children and adolescents, Funding: G-BA Innovation fund |
ESG-study | B/ Grasemann E / Hebebrand, Hinney |
Assessment of hormonal and nutritional status in >400 children and adolescents with depressive symptoms, Funding: intramural |
European Reference Networks MetabERN, Endo-ERN, ERK-Net, ERN-EuroBloodNet, ERN-Paedcan, ENERCA, ERN-Lung |
A / B / C / D / E | European Reference Networks (ERN) for metabolism, endocrinology, hematology, oncology, rare congenital anaemias, and pulmonology, Funding: EU |
ADOPT | C / Doepfner | Optimization of prevention and therapy in patients with affective dysregulation, Funding: BMBF |
B-FAST | C / Bender, Doetsch | Applied surveillance Covid-19 in day care centers and schools, Funding: BMBF |
HSR-NICU, NEO-CamCare, and NEO-MILK | C / Pfaff | Implementation of health services research to improve care of very-low-birth infants in neonatal intensive care units (HSR-NICU), e.g. using webcams (NeoCamCare) or via implementation of donor milk banks and structured breastfeeding strategies (NEO-Milk), Funding: G-BA Innovation fund |
National reference center for molecular diagnostics in neuroblastoma and national biobank for neuroblastoma | C / Fischer | Analysis of the postnatal parental-newborn skin-skin contact for stress programming, Funding: BMBF |
ForMe/ ARegPKD / ADPedKD registers | C / Liebau, Liebau, E / Pape, Ahlenstiel-Grunow |
Clinical characterization of patients suffering from nephrotic syndrome (ForMe) and hepatorenal diseases (ARegPKD, ADPedKD), Funding: DFG, BMBF, Marga&Walter Boll foundation, intramural |
ADEBAR | C / Joisten (DSHS) | Obesity prevention through a nutrition- and exercise-based family program, Funding: Marga&Walter Boll foundation |
CHILT-III | C / Joisten (DSHS) | Outpatient multidisciplinary family-based program for obese children (ca. 500), Funding: health insurance (AOK), intramural |
CoRe-Net | C / Pfaff | Research network for the care of vulnerable patient groups with a comprehensive database containing GKV routine data of 4 cooperating german health insurances, Funding: BMBF |
PARTCHILD program | C / De Bock (BZgA) | Improving the quality of care for children with chronic diseases and disabilities in social pediatric centers, Funding: G-BA Innovation fund |
PEACHES cohort (Programming of enhanced adiposity risk in childhood – early screening) |
D / Ensenauer | 1707 pairs of mothers (with pregestational obesity) and children, including biobank and biosamples. Funding: BMBF |
PEPO cohort (Perinatal prevention of obesity development) |
D / Ensenauer | 11,730 mother-child pairs analyzing the longitudinal effects of prepregnancy BMI and gestational weight gain on offspring. Funding: BMBF |
BEARR (Breastfeeding education for risk reduction) project | D / Ensenauer | Extensive breastfeeding support program for obese mothers at high-risk of diabetes as an early preventive measure for mother and child. Funding: Foundation for Cardiovascular Prevention in Childhood, Ludwig-Maximilians-Universität München |
COACH. Chronic Conditions in Adolescents: Implementation and Evaluation of Patient-centred Collaborative Health Care | D / Meissner | Motivational Interviewing as a tool to enhance access to mental health treatment in adolescents with chronic medical conditions and need for psychological support (COACH-MI); Funding: BMBF |
Preterm Follow-up cohort (partner of GNN) | E / Felderhoff-Müser | > 1000 preterm born infants (<32 weeks gestation) with MRI at TEA (>1100 scans), aEEG in the first 72hrs of life, GMA, HINE etc., and long-term neurodevelopmental follow-up. Funding: Mercator, BMBF |
NEOCYST (Network for early onset cystic kidney disease) | E / Pape C / Liebau |
NEOCYST network aimed to improve knowledge of the genetics, molecular pathophysiology, and long-term prognosis of cystic kidney disease, Funding: BMBF |
Active Onco Kids network | E / Reinhardt, C /Fischer | Large German Cancer Aid-funded national network to promote and evaluate the benefits of sports in severe and chronic diseases, Funding: German Cancer Aid |
TELE-KASPER | E / PI Felderhoff-Müser | Antibiotic Stewardship in Pediatrics – interprofessional telemedicine network, Funding: G-BA Innovation fund |
CARE for CAYA project | E / Reinhardt | Prevention program for young patients after surviving cancer in childhood, adolescence, and young adulthood, Funding: G-BA Innovation fund |
KTX360° | E / Ahlenstiel-Grunow, Pape | A multicenter, multisectoral, multimodal, telemedicine-based followup care model to improve care and reduce health care costs after kidney transplantation in children and adults, Funding: G-BA Innovation fund |
Name | Location / Principle Investigators | Project title |
---|---|---|
CRC 1382 Gut-liver axis |
A / Wagner | Coordination of gut-liver communication by directed immune cell migration (B02) |
CRC 1280 Extinction learning |
B / Elsenbruch | From Pavlov to pain: extinction learning in visceral pain (A10) The impact of inflammation on the extinction of pain-related fear in humans (A12) |
CRC289 Treatment expectation |
B / Elsenbruch | Effects of negative expectations on visceroception and visceral pain (TP04) |
CRC1399 Mechanisms of drug sensitivity and resistance in small cell lung cancer |
C / Fischer | Targeting telomere maintenance mechanisms in SCLC (A03) |
CRC 1451 Motor control |
C / Bender | Multidimensional aspects including the development of motor control |
iRTG 2150 | A / Konrad, Eickhoff (RCJ) | The Neuroscience of Modulating Aggression and Impulsivity in Psychopathology |
RTG 2576 | D / Ensenauer | In vivo investigations towards the early development of type 2 diabetes (vivid) |
RU FOR2722 Musculoskeletal extracellular matrix |
C / Brachvogel, Dötsch | Mitochondrial dysfunction in cartilage and its consequences for ECM and joint homeostasis (M1); Musculoskeletal ECM-induced reprogramming of the metabolic system (M2) |
CRU 337 Phenotypic therapy and immune escape in cancer (PhenoTime) |
D / Remke | Identification and functional characterization of long non-coding RNAs as epigenetic determinants of therapy resistance in BRAF-driven cancers (P6) |
RESOLV Excellence Cluster |
B / Winklhofer | Cellular quality control and stress response pathways in neurodegeneration |
CECAD Excellence Cluster |
C / Alejandre Alcazar, Brüning | Metabolic origins of premature ageing of the lung (Alejandre Alcazar); Regulation of food intake and influences energy availability in the body (Brüning) |
West German Genome Center (WGGC) | A / C / D/ E | DFG-funded collaborative network, one of four national Next Generation Sequencing Competence Centers |
Leibniz Center for Diabetes Research | D / Meissner | State-of-the-art research center for diabetes. |
Institute of Human Genetics | D / Borkhardt | Analysis of genetic causes of disease |
Dept.s of Computational Cancer Biology, Translational Genomics and Institute for Pathology | C / Fischer | Computer-based analyses of the tumor biology and micro-environment. |
Seven collaborating community-based hospitals for Pediatrics and Child&Adolescent Medicine in NRW | ABCDE / INTERPLAY | Within NRW, six Clinics for pediatrics or Clinics for child & adolescent psychiatry committed to collaborate in ongoing and future patient’s cohorts and research activities in INTERPLAY. Bielefeld (https://evkb.de/); Cologne (https://www.kliniken-koeln.de/); Dortmund (https://www.klinikumdo.de/); Duesseldorf (https://www.evk-duesseldorf.de/); Krefeld (https://www.helios-gesundheit.de/kliniken/krefeld/); Minden (https://www.muehlenkreiskliniken.de/); Viersen (https://klinik-viersen.lvr.de/). |
Regional state youth welfare organizations | ABCDE / INTERPLAY | Both regional state youth welfare organizations support INTERPLAY LVR-Regional Children (www.lvr.de); LWL-Regional (www.lwl.org) |
Name | Location / Principle Investigators | Project title |
---|---|---|
German Diabetes Centre (DZD) | C / Brüning | |
German Centre for Lung Research (DZL) | C / Alejandre Alcazar | Converging signaling pathways in neonatal lung regeneration |
German Cancer Consortium for Translational Cancer Research (DKTK) | D/ Marc Remke | Pediatric Neuro-Oncogenomics |
Max Rubner-Institut (MRI) - Federal Research Institute of Nutrition and Food | D / Ensenauer (Head of the Dept. of Child Nutrition) | Developmental origins of obesity and nutrition-related diseases |
TU Munich and Leibniz-Institute for Food Systems Biology | D / Ensenauer | Developmental origins of obesity and nutrition-related diseases |
German Neonatal Network (GNN) | E / Felderhoff-Müser | Early markes for neurological outcome of preterm infants |
German Centre for Cardiovascular Research (DZHK) | E / Felderhoff-Müser | Cardiovascular complication in pregnancy – neurodevelopmental outcome |
NAKO Working Group “Birth Cohort” Speaker: Dr. Börge Schmidt https://nako.de/ |
E/ Felderhoff-Müser | The German National Cohort (NAKO) is a large-scale cohort study that investigates risk factors for a broad range of diseases (~200.000 participants aged 20-70 years; 18 study regions in Germany). |
Four health insurances: AOK Rheinland/Hamburg (https://www.aok.de/pk/rh/); Barmer (https://www.barmer.de/); DAK (https://www.dak.de/dak/); IKK (https://www.ikk-classic.de/); TK (https://www.tk.de/) |
ABCDE / INTERPLAY partner-site | These health insurances have confirmed their interest in collaborating with INTERPLAY, e.g. by providing access to diseases information, expanding structures such as CoRe-Net (Table 2) or supporting advisory boards (Fig. 10). |
Seven patients’ organizations | ABCDE / INTERPLAY | European Foundation for the Care of Newborn Infants (EFCNI; https://www.efcni.org/); German Rheumatism League NRW (https://www.rheuma-liga.de/); German Crohn's disease /Ulcerative colitis association (https://www.dccv.de/); rehaKIND (https://www.rehakind.de/); ADHD association (http://www.adhs-deutschland.de/); Löwenstern (support for children with cancer; https://www.loewenstern-ev.de/); Child Protection Association (www.kinderschutzbund.de) |
Name | University Hospital | Project title |
---|---|---|
European Network on Hyperkinetic Disorders (EUNETHYDIS) | A / Konrad, B / Holtmann, C / Doepfner | Hyperkinetic disorders in children and adolescents |
Connect4children | B / Lücke E / Felderhoff-Müser |
Collaborative European network that aims to facilitate the development of new drugs and other therapies for the entire paediatric population |
CERTAIN-Regsitry for Kidney and liver transplantation | E / Pape C / Liebau |
Co-Lead of Cooperative European Paediatric Renal Transplant Initiative |
ARegPKD | C / Liebau | European network of paediatric nephrologists from 15 European countries in cooperation with geneticists collect clinical data of patients with ARPKD. |
European ADHD Guidelines Group (EAGG) | B / Holtmann, C / Doepfner |
Attention deficit hyperactivity disorder in children and adolescents |
CCB&B Development | C / Boenisch | Development of bilingual communication boards for students with complex communication needs. |
LEGEND (Leukemia Gene Discovery) EU framework | D / Borkhardt | Identification of genetic variants that confer susceptibility for pediatric leukemia or lymphoma development |
Harmony Alliance | D / Borkhardt, Meisel E / Reinhardt |
European Public-Private Partnership for big data in hematology |
EU PREMSTEM consortium | E / Felderhoff-Müser | Mechanisms of stem cell therapy on different models of brain damage in premature infants |
ENERCA | E / Reinhardt | European network for rare and congenital anaemias |
Pediatric Acute Leukemia (PedAL)/European Pediatric Acute Leukemia (EuPAL) Initiative | E / Reinhardt (Director of the consortium) | Pediatric Acute Leukemia Initiative |
Innovative Therapies for Children with Cancer Paediatric Preclinical Proof-of-concept Platform (ITCC) | E / Reinhardt | Development and establishment of preclinical models of high-risk pediatric solid tumors |
EuRR-BONE; Registry of the ERN BOND | B / Grasemann | Development and establishment of a European Registry for Rare Bone Diseases |
An exampel of cooperation: Anorexia nervosa